INGREDIENTS

INGREDIENTS GROWTH FACTORS    주소복사

GROWTH FACTORS

 



LayN-EGF

 


  -. LayN-EGF is a recombinant protein combining LayN-Pep and Human EGF (Epidermal Growth Factor)

 

  -. EGF protein was discovered at 1962 by Dr. Stanley Cohen. This work led to the 1986 Nobel Prize in

     Physiology or Medicine

 

  -. EGF is a growth factor that stimulates cell growth, proliferation, differentiation and survival by binding

     to its receptor EGFR

  

 Functions

  ● Cell Proliferation & Differentiation

     Stimulate skin cell growth, proliferation & differentiation

     (Sources: CRC Crit. Rev. Biochem. 1983;14(2):93-111, Dev. Cell. 2013 13;25(3):229-240)

  ● Increase Collagen, Elastin, Hyaluronic acids

     Activate fibroblast growth: Increase collagen, elastin, hyaluronic acids

     (Source: Biochem. J. 1987 15;247(2):385-388)

  ● Anti-Inflammation

     Reduction of skin irritation

     (Source: Skin Pharmacol. Appl. Skin Physiol. 1999;12(1-2):79-84)

  ● Wound Healing

     Mitigate skin faults

     (Source: N. Engl. J. Med. 1989 13;321(2):76-79)

 

 

 

LayN-KGF

 

  -. LayN-KGF is a recombinant protein combining LayN-Pep and Human KGF (Keratinocyte Growth Factor)

 

  -. KGF (Syn. FGF-7, Fibroblast Growth Factor-7) is a growth factor that stimulates cell growth and proliferation

     in diverse cell types including keratinocytes

 

  -. KGF is mainly synthesized in fibroblasts and bind to its receptor KGFR in keratinocytes

 

 Functions

  ● Hair Growth

     Hair follicles growth & differentiation

     (Source: J. Invest. Dermatol. 2000;114(4):667-673)

  ● Inhibition of Hair Loss

     Inhibition of hair loss during radiation therapy

     (Source: Am. J. Pathol. 1995;147(1):145-154)

  ● Cell Growth & Differentiation

     Stimulate cell growth & differentiation in diverse cell types including keratinocytes

     (Source: Cell Biol. Int. 1995;19(5):399-411)

  ● Wound Healing

     Wound repair with another GFs like EGF and FGF. Mitigate skin faults

     (Source: Oncogene 1999 18;18(48):6667-6676)

 

 

 

LayN-aFGF

 

  -.  LayN-aFGF is a recombinant protein combining LayN-Pep and Human aFGF (acidic Fibroblast Growth Factor)

 

  -. aFGF (Syn. FGF-1) is a growth factor that stimulates cell proliferation, differentiation and protein synthesis in

     diverse cell types

 

 Functions

  ● Hair Growth

     Hair follicles growth. Modulation of hair growth cycle

     (Source: Biomed. Res. Int. 2015;2015:730139)

  ● Induction of Angiogenesis

     Angiogenesis in injured tissues. Wound repair

     (Source: Prog. Growth Factor Res. 1990;2(1):71-79)

  ● Cell Proliferation & Differentiation

     Stimulate cell proliferation & differentiation in diverse cell types

     (Source: Postepy. Hig. Med. Dosw. 1999;53(2):277-289)

  ● Wound Healing

     Wound repair with another GFs like EGF and FGF. Mitigate skin faults

     (Sources: Growth Factors 1992;7(1):1-14, J. Invest. Dermatol. 1995;104(5):850-855)

 

 

 

LayN-bFGF

 

  -. LayN-bFGF is a recombinant protein combining LayN-Pep and Human bFGF (basic Fibroblast Growth Factor)

 

  -. bFGF (Syn. FGF-2) is a growth factor that modulates embryonic cell proliferation and wound repair.

  

  -. bFGF is mainly present basement membranes and in the subendothelial extracellular matrix of blood vessels

 

 Functions

  ● Wound Healing

     Wound repair by stimulate collagen synthesis & angiogenesis in injured tissues

     (Sources: J. Surg. Res. 1988;45(1):145-153, Trends Pharmacol. Sci. 1988;9(12):427-428)

  ● Fibroblasts Proliferation

     Stimulate growth & proliferation of fibroblasts which synthesize collagen, elastin and hyaluronic acids

     (Source: Br. J. Dermatol. 2010;162(4):717-723)

  ● Induction of Angiogenesis

     (Source: Nat. Med. 1997;3(2):158-164)

  ● Hair Growth

     Hair follicles proliferation. Modulation of hair growth cycle

     (Sources: Biomed. Res. Int. 2015;2015:730139)

 

 

 

LayN-IGF1

 

  -. LayN-IGF1 is a recombinant protein combining LayN-Pep and Human IGF1 (Insulin-like Growth Factor 1)

 

  -. IGF1 is a growth factor that structurally resembles with insulin and modulates cell growth and proliferation

     in diverse cell types

 

  -. IGF1 is mainly synthesized in liver and translocate to diverse tissues through blood vessels and acts its

     functions by bind to its receptor IGF1R

 

 Functions

  ● Hair Growth

     Hair follicles proliferation & differentiation. Modulation of hair growth cycle.

     Stimulate hair shaft differentiation

     (Sources: Dermatol. Online J. 1995;5(2):1, J. Invest. Dermatol. 2005;125(5):873-882)

  ● Keratinocytes Growth & Proliferation

     Stimulate keratinocytes growth & proliferation by bind to IGF1R

     (Source: J. Invest. Dermatol. 1994;103(5):627-631)

  ● Stimulate Collagen Synthesis

     Stimulate collagen synthesis: Anti-wrinkle by increasing the skin volume

     (Source: J. Biol. Chem. 2014 14;289(11):7264-7274)

 

 

 

LayN-VEGF

 

  -. LayN-VEGF is a recombinant protein combining LayN-Pep and Human VEGF-A (Vascular Endothelial

     Growth Factor A)

 

  -. VEGF is a growth factor that modulates vasculogenesis and angiogenesis

 

 Functions

  ● Vasculogenesis & Angiogenesis

     Stimulate endothelial cell proliferation & migration

     (Source: FASEB J. 1999;13(1):9-22)

  ● Hair Growth

     Stimulate hair follicles proliferation & hair growth by forming blood vessels in hair follicles

     (Source: J. Clin. Invest. 2001 15;107(4):409-417)

  ● Wound Healing

     Stimulate blood vessels forming and skin cell migration in injured tissues

     (Source: Am. J. Pathol. 1998;152(6):1445-1452)